Intraarticular Injection of High-Molecular Hyaluronic Acid:An Experimental Study on Normal Adult Rabbit Knee Joints
نویسندگان
چکیده
منابع مشابه
Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model.
OBJECTIVES We hypothesized that high-molecular-weight (MW) cross-linked (CL) hyaluronic acid (HA) improves joint lubrication and has an enhanced chondroprotective effect. We examined the histopathological changes and friction coefficients in osteoarthritic knee joints after injecting high-MW CL HA. DESIGN A bilateral anterior cruciate ligament transection (ACLT) model in 20 Japanese white rab...
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The aim of this study was to examine the effects of intraarticular administration of hyaluronan (HA) on cartilage degradation. Using a partial menisectomy model of osteoarthritis (OA) in the rabbit knee, the authors investigated the catabolic and anabolic changes induced by intraarticular injection of HA. To analyze anabolic changes, the authors assessed cell proliferation by measuring [3H] thy...
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Objective. To evaluate the efficacy and safety of injection of high molecular weight (HMW) hyaluronan (Orthovisc®) in patients with mild, moderate, and severe knee osteoarthritis (OA). Methods. A randomized, arthrocentesis-controlled, multicenter trial. Patients (n = 372) were randomized to 4 weekly HMW hyaluronan injections (O4, n = 128), 3 weekly HMW hyaluronan injections followed by one arth...
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Hyaluronic acid (HA) is found in high concentrations in cartilage and synovial fluid, and is an important component of the extracellular matrixes-exerting joint lubrication and buffering actions thanks to its viscoelastic properties. The present study examines the scientific evidence found in the current literature on the usefulness of the intraarticular injection of HA in patients with temporo...
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Although articular hyaline cartilage typically has low potential for regeneration, numerous methods and techniques have been proposed to induce the reparation process. In our work, we used microfracture techniques in combination with intraarticular application of hyaluronic acid in rabbit knee articular cartilage defect. In comparison with the control group, after 6 and 10 weeks we observed a h...
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ژورنال
عنوان ژورنال: Acta Orthopaedica Scandinavica
سال: 1976
ISSN: 0001-6470
DOI: 10.3109/17453677608988724